| Certification Type: |
Professional Affiliation, American Academy of Arts and Sciences
Professional Affiliation, National Academy of Sciences
Professional Affiliation, Institute of Medicine
Professional Affiliation, 1990
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| Medical Degree: |
M.D., Stanford University School of Medicine, 1976
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| Degree: |
B.S., Cornell University, 1971
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| Medical Experience: |
Fellowship, Center for Cancer Research, MIT
Fellowship, Stanford University School of Medicine
Fellowship, American Academy of Microbiology , 1997
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| Laboratory Address: |
Laboratory
MRL
Los Angeles, CA 90095
UNITED STATES
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| Work Address: |
Office
MRL
Los Angeles, CA 90095
UNITED STATES
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| Work Address: |
5-748 MRL
CAMPUS - 166222
CA 90095
UNITED STATES
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Work Phone Number:
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(310) 206-0386
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Dr. Witte is also Professor of Microbiology, Immunology, and Molecular Genetics at the University of California, Los Angeles, where he holds the President's Chair in Developmental Immunology, and Professor of Molecular and Medical Pharmacology at the David Geffen School of Medicine, UCLA; and Founding Director of the Institute for Stem Cell Biology and Medicine recently renamed as the Eli and Edythe Broad Center of Regenerative Medicine nad Stem Cell Research at UCLA. He received his B.S. degree from Cornell University, his M.D. degree from Stanford University, and completed his postdoctoral training at the Massachusetts Institute of Technology. Dr. Witte's honors include the Milken Foundation Award in basic cancer research, the Rosenthal Award of the American Association for Cancer Research, the Dameshek Prize from the American Society of Hematology, the Warren Alpert Foundation Prize, and the de Villiers International Achievement Award from the Leukemia and Lymphoma Society. He is a member of the American Academy of Arts and Sciences, the American Academy of Microbiology, the National Academy of Sciences, and the Institute of Medicine of the NAS. Dr. Witte was named the 2007 UCLA Faculty Research Lecturer. He currently serves on several editorial and advisory boards.
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Bailey, RC, Kwong, GA Radu, CG, Witte, ON, Heath, JR DNA-Encloded Antibody Libraries: Platform for Multiplexed Cell Sorting and Detection of Genes and Proteins.
J Am Chem Soc..
2007;
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Lawson, DA, Xin, L, Lukacs, RU, Cheng, D, Witte, ON Isolation and functional characterization of murine prostate stem cells.
Proc Natl Acad Sci U S A.
2007; 104(1):
181-6.
Radu, CG, Shu, CJ, Shelly, SM, Phelps, ME, Witte, ON Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis.
Proc Natl Acad Sci U S A.
2007; 104(6):
1937-42.
Khan, AQ, Sen, G, Guo, S, Witte, ON, Snapper, CM Induction of in vivo anti-polysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell ceceptor signaling than antiprotein responses.
Infect. Immun..
2006; 74(2):
1419-24.
Lei Q, Jiao J, Xin L, Chang C, Wang S, Gao J, Gleave ME, Witte ON, Liu X, Wu H NKX3.1 Stabilizes p53, Inhibits AKT Activation and Blocks Prostate Cancer Initiation Caused by PTEN Loss.
Cancer Cell.
2006; 9(5):
367-78.
Radu CG, Cheng D, Nijagal A, Riedinger M, McLaughlin J, Yang LV, Johnson J, Witte ON Normal Immune Development and Glucocorticoid-induced Thymocyte Apoptosis in Mice Deficient for the T-Cell Death-Associated Gene 8 Receptor.
Mol. Cell. Biol.
2006; 26(2):
668-77.
Yang, LV, Radu, CG, Roy, M, Lee, S, McLaughlin, J, Teitell, MA, Iruela-Arispe, ML, Witte, ON
2006. . Epub ahead of print 2006 Dec 4 Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor.
Mol Cell Biol..
2006; 27(4):
1334-47.
Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.
Proc Natl Acad Sci U S A.
2005; 102(5):
1632-7.
Wang LR, Yang CG, Bentolila LV, Riedinger LA, Witte ON Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A..
Molecular biology of the cell. .
2005; 16(5):
2234-47.
Lee CC, Sui G, Elizarov A, Shu CJ, Shin YS, Dooley AN, Huang J, Stout D, Kolb HC, Witte ON, Satyamurthy N, Heath JR, Phelps ME, Quake SR, Tseng HR Multi-Step Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics.
Science.
2005; 310(5755):
1793-6.
Lawson, DA, Xin, L, Lukacs, R, Xu, Q, Cheng, D, Witte, ON Prostate Stem Cells and Prostate Cancer.
Cold Spring Harbor Symp. Quant. Biol..
2005; 70:
187-96.
Kim YJ, Dubey P, Ray P, Gambhir SS, Witte ON Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a tri-fusion reporter gene.
Molecular Imaging and Biology.
2004; 6(5):
331-40.
Kharas MG, Deane JA, Wong S, O'Bosky KR, Rosenberg N, Witte ON, Fruman DA Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells..
Blood. .
2004; 103(11):
4268-75.
Wong S, McLaughlin J, Cheng D, Zhang C, Shokat KM, Witte ON Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations..
Proc Natl Acad Sci U S A.
2004; 101(50):
17456-61.
Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer..
Blood. .
2004; 104(5):
1281-90.
Radu CG, Yang LV, Riedinger M, Au M, Witte ON T cell chemotaxis to lysophosphatidylcholine through the G2A receptor..
Proc Natl Acad Sci U S A.
2004; 101(1):
245-50.
Wong S, McLaughlin J, Cheng D, Witte ON Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors..
Blood. .
2003; 101(10):
4088-97.
Ferl GZ, Timmerman JM, Witte ON Extending the utility of gene profiling data by bridging microarray platforms..
Proc Natl Acad Sci U S A.
2003; 100(19):
10585-7.
Whyburn LR, Halcomb KE, Contreras CM, Pappu R, Witte ON, Chan AC, Satterthwaite AB Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase..
International immunology. .
2003; 15(3):
383-92.
Wong S, McLaughlin J, Cheng D, Shannon K, Robb L, Witte ON IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease..
Proc Natl Acad Sci U S A.
2003; 100(20):
11630-5.
Xin L, Ide H, Kim Y, Dubey P, Witte ON In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme..
Proc Natl Acad Sci U S A.
2003; 100 Suppl 1:
11896-903.
Dubey P, Su H, Adonai N, Du S, Rosato A, Braun J, Gambhir SS, Witte ON Quantitative imaging of the T cell antitumor response by positron-emission tomography.
Proc Natl Acad Sci U S A.
2003; 100(3):
1232-7.
Whyburn LR, Halcomb KE, Contreras CM, Lowell CA, Witte ON, Satterthwaite AB Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice..
Journal of immunology (Baltimore, Md. : 1950) .
2003; 171(4):
1850-8.
Le LQ, Kabarowski JHS, Wong S, Nguyen K, Gambhir SS, Witte ON Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene.
Cancer Cell.
2002; 1(4):
381-391.
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